PUBMED SEARCH (Mostly but not completely inclusive or specific)

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• Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice. Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li & Calvin J. Kuo. Nature Communications. May 2023. 14: 2947. https://doi.org/10.1038/s41467-023-37689-1. LINK
   

• Deterministic evolution and stringent selection during preneoplasia. Kasper Karlsson, Moritz J. Przybilla, Eran Kotler, Aziz Khan, Hang Xu, Kremena Karagyozova, Alexandra Sockell, Wing H. Wong, Katherine Liu, Amanda Mah, Yuan-Hung Lo, Bingxin Lu, Kathleen E. Houlahan, Zhicheng Ma, Carlos J. Suarez, Chris P. Barnes, Calvin J. Kuo & Christina Curtis. Nature. May 2023. 618: 383–393. https://doi.org/10.1038/s41586-023-06102-8. LINK

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• A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Yuan-Hung Lo, Kevin S Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D Sobba, Kasper Karlsson, Sunny J Jones, Teri A Longacre, Amanda T Mah, Bahar Tercan, Alexandra Sockell, Hang Xu, Jose A Seoane, Jin Chen, Ilya Shmulevich, Jonathan S Weissman, Christina Curtis, Andrea Califano, Haian Fu, Gerald R Crabtree, Calvin J Kuo. Cancer Discovery. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15. PMID: 33451982. LINK​   

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• Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.  Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS,  Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ.   Nature  2020 Dec;588(7839):670-675. doi: 10.1038/s41586-020-3014-1. Epub 2020 Nov 25.  PMID: 33238290. LINK
   

• Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. Cell Stem Cell. 2020 Aug 14:S1934-5909(20)30358-1. doi: 10.1016/j.stem.2020.07.020. LINK

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• Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells. Ding S, Song Y, Brulois KF, Pan J, Co JY, Ren L, Feng N, Yasukawa LL, Sánchez-Tacuba L, Wosen JE, Mellins ED, Monack DM, Amieva MR, Kuo CJ, Butcher EC, Greenberg HB. Gastroenterology. 2020 Jul;159(1):214-226.e1. doi: 10.1053/j.gastro.2020.03.053. Epub 2020 Apr 1. PMID: 32247021 LINK

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• CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC. Nature. 2020 Apr;580(7801):136-141. doi: 10.1038/s41586-020-2099-x. Epub 2020 Mar 11. PMID: 32238925 LINK

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• High-Efficiency, Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia. Vaidyanathan S, Salahudeen AA, Sellers ZM, Bravo DT, Choi SS, Batish A, Le W, Baik R, de la O S, Kaushik MP, Galper N, Lee CM, Teran CA, Yoo JH, Bao G, Chang EH, Patel ZM, Hwang PH, Wine JJ, Milla CE, Desai TJ, Nayak JV, Kuo CJ, Porteus MH. Cell Stem Cell. 2020 Feb 6;26(2):161-171.e4. doi: 10.1016/j.stem.2019.11.002. Epub 2019 Dec 12.
  PMID: 31839569 LINK  

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• Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions. Co JY, Margalef-Català M, Li X, Mah AT, Kuo CJ, Monack DM, Amieva MR. Cell Rep. 2019 Feb 26;26(9):2509-2520.e4. doi: 10.1016/j.celrep.2019.01.108.
  PMID: 30811997  LINK

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• Neal JT, Li X, Zhu J, Giangarra V, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Ju J, Liao L, Zemek AJ, Zhao F, Karlsson K, Shultz LM, Metzner TJ, Nadauld LD, Tseng Y-Y, Alkhairy S, Oh C, Keskula P, Mendoza-Villanueva D, De La Vega FM, Kunz PL, Leppert J, Sunwoo JB, Sabatti S, Boehm JS, Hahn WC, Zheng GXY, Davis MM, Kuo CJ. Organoid modeling of the tumor immune microenvironment.  Cell (2018) Dec 13;175(7):1972-1988.e16. doi: 10.1016/j.cell.2018.11.021. PMID: 30550791. LINK

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• Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ. A RECK-WNT7 receptor-ligand interaction enables isoform-specific regulation of Wnt bioavailability. Cell Reports (2018) Oct 9;25(2):339-349.e9. doi: 10.1016/j.celrep.2018.09.045. PMID:30304675. LINK

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• Zhang B, Nguyen LXT, Li L, Zhao D, Kumar B, Wu H, Lin A, Pellicano F, Hopcroft L, Su YL, Copland M, Holyoake TL, Kuo CJ, Bhatia R, Snyder DS, Ali H, Stein AS, Brewer C, Wang H, McDonald T, Swiderski P, Troadec E, Chen CC, Dorrance A, Pullarkat V, Yuan YC, Perrotti D, Carlesso N, Forman SJ, Kortylewski M, Kuo YH, Marcucci G. Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Nature Medicine 2018 May; PMID: 29505034 LINK

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• Kuo CJ, Curtis C, Organoids reveal cancer dynamics, Nature. 2018 Apr;556(7702):441-442. doi: 10.1038/d41586-018-03841-x. LINK

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• Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.  Nature (2017) May 11;545(7653):238-242. doi: 10.1038/nature22313. Epub 2017 May 3. PMID: 28467820 LINK

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• Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.  Nature (2017) May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3. PMID: 28467818 LINK

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• Chang J, Mancuso MR, Maier C, Liang X, Yuki K, Yang L, Kwong JW, Wang J, Rao V, Vallon M, Kosinski C, Zhang JJ, Mah AT, Xu L, Li L, Gholamin S, Reyes TF, Li R, Kuhnert F, Han X, Yuan J, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier SH, Shortliffe LD, Wu X, Snyder M, Chan P, Giffard RG, Chang HY, Andreasson K, Kuo CJ. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nature Medicine (2017) Mar 13. doi: 10.1038/nm.4309. PMID: 28288111 LINK

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• Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature Medicine (2017) Feb;23(2):174-184. doi: 10.1038/nm.4267. PMID: 28092664 LINK

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• Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ. Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture.  Nature Medicine. (2014) Jul;20(7):769-77. doi: 10.1038/nm.3585. Epub 2014 May 25. PMID: 24859528 LINK

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• Lim X., Tan SH, Koh WLC, Chau RMW, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science, Dec 6;342(6163):1226-30. doi: 10.1126/science.1239730. (2013). LINK

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• Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton LC, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes JP, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.  Nature Medicine Oct;19(10):1331-7 (2013). doi: 10.1038/nm.3295. PMID: 24037094 Commentary in Science Signaling. Selected by F1000. LINK

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• Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, Lagory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nature Medicine. Oct;19(10):1325-30 (2013). doi: 10.1038/nm.3294. PMID: 24037093 Commentary in Science Signaling. Selected by F1000. LINK

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• Barry ER, Morikawa T, Butler BL, Shrestha K, Fuchs CS, de la Rosa, Yan KS, Magness ST, Ogino S, Kuo CJ, and Camargo FD. Restriction of intestinal stem cell expansion and the regenerative response by YAP.  Nature. (2013) Jan 3;493(7430):106-10. PMCID: PMC3536889.. Commentary in Cell Stem Cell. Selected by F1000. LINK

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• Rosenbluh, J, Nijhawan D, Cox A, Li X, Neal, JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC. β-catenin driven cancers require a YAP1 transcriptional regulatory complex for survival and tumorigenesis.  Cell (2012) Dec 21;151(7):1457-73. PMCID: PMC3530160. Selected by F1000. LINK

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• Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR and Kuo CJ. Bmi1 and Lgr5 mark functionally distinct intestinal stem cells. Proc. Natl. Acad. Sci. USA, (2012) Jan 10;109(2):466-71. Epub (2011) Dec 21. PMID: 22190486 LINK

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• McGinnis, L. and Kuo, CJ. PDGF-B exploits stromal Epo.  Nature Medicine, (2012) Jan 6;18(1):22-4. PMID: 222276606. LINK

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• Kuhnert F. Mancuso MR, Wang H, Shamloo A, Choksi V, Su H, Young WL, Heilshorn S and Kuo CJ. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science, Nov 12;330(6006):985-9. (2010). Commentary in Science Translational Medicine LINK

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• Chan CKF, Chen CC, Luppen CA, Kraft DL, Kim JB, DeBoer A, Wei K, Helms JA, Kuo CJ, Kraft DL, Weissman IL. Endochondral ossification is required for hematopoietic stem cell niche formation.  Nature (2009) Jan 22;457(7228):490-4. doi: 10.1038/nature07547. Epub 2008 Dec 10. PMID: 19078959 PMCID: PMC2648141 LINK

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• Daneman R, Agalliu D, Zhou L, Kuhnert F., Kuo CJ and Barres BA. Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A, (2009) Jan 13;106(2):641-6. Epub 2009 Jan 7. (2009). LINK

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• Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Ootani A, Li X, Ueno H, Sangiorgi E, Ho QT, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, and Kuo CJ.  Nature Medicine, Jun;15(6):701-6 (2009). Epub 27 April 2009. Cited by Faculty of 1000, Commentary by Nature Methods LINK

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• Kuhnert F, Mancuso MR, Stankunas K, Hampton J, Asano T, Chen CZ and Kuo CJ. Attribution of Angiogenesis Phenotypes of the Murine Egfl7 Locus to the microRNA miR-126. Development Dec;135(24):3989-93. Epub 2008 Nov 5. (2008). Cited in Science STKE. Selected by F1000. LINK

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• Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ. Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A. (2008) Jul 22;105(29):10185-90. Epub 2008 Jul 16. LINK

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• Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine. Jul;12(7):793-800. (2006). * Also see related commentary Fischer C, Carmeliet P, Conway VEGF inhibitors make blood. Nature Medicine 2006 Jul;12(7):732-4. LINK